Raws li kev txheeb cais ntawm Zhiliwo Big Data Platform, qhov cuam tshuam qhov nruab nrab ntawm kev hais txog Foregene SCI cov ntaub ntawv nyob rau lub Ob Hlis 2022 yog siab li 5.8, thiab qhov cuam tshuam ntau tshaj plaws yog 8.947.
Los ntawm kev txheeb xyuas cov naj npawb ntawm SCI cov ntaub ntawv ntawm Foregene cov khoom nyob rau hauv lub xyoo, nws tau pom tias txoj kev loj hlob yog pom tseeb.
Foregene Co., Ltd. yog tsim nyob rau hauv 2011. Nws yog ib tug biotechnology enterprise integrating R&D, ntau lawm, muag khoom thiab cov neeg siv khoom.Txij li thaum nws tsim, nws tau tsom mus rau txoj kev loj hlob ntawm molecular thiab cell biology ntsig txog technologies, cov khoom thiab cov kev pab cuam, thiab muab nucleic acid purification, nucleic acid nrhiav thiab lwm yam kev daws rau feem coob ntawm cov neeg siv.Nws txoj kev tshawb fawb cov khoom lag luam suav nrog RNA purification series, DNA purification series, RT / RT-PCR series, direct PCR series, PCR Mix series, direct RT-qPCR series thiab "Sui" series of molecular related instruments.Cov khoom lag luam tau siv dav hauv kev tshawb fawb hauv kev tshawb fawb txog lub neej, tshuaj, kev ua liaj ua teb, tshuaj, thiab ib puag ncig.Cov neeg siv khoom nyob hauv cov tsev kawm ntawv qib siab, cov koom haum tshawb fawb, tsev kho mob thiab lwm chav.
ZhiLiaowo tau xaiv 6 cov ntaub ntawv tau qhab nia siab ntawm Foregene thaum Lub Ob Hlis rau kev siv ntawm cov kws tshawb fawb, kom muaj kev nkag siab tob dua thiab paub txog cov khoom Foregene.
Kab lus lub npe: Substrate txhav tswj kev sib txawv ntawm induced pluripotent qia hlwb rau hauv lub plawv valve endothelial hlwb
DOI: 10.1016/j.actbio.2022.02.032
Sijhawm tso tawm: 2022-2-27
Foregene
Cov ntaub ntawv hais txog cov khoom
Lub Npe Lub Npe: Kev txheeb xyuas qhov muaj peev xwm Mitochondrial Proteome Kos npe koom nrog Pathogenesis ntawm Pulmonary Arterial Hypertension hauv tus qauv nas
PIB: 10.1155.2022/8401924
Sijhawm tso tawm: 2022-2-21
Sau Kev Koom Tes: Department of Pharmacy, First Affiliated Hospital of Xinjiang Medical University.
Paub meej: Pulmonary arterial hypertension (PAH) yog ib yam kab mob loj thiab loj heev uas cuam tshuam rau lub plawv thiab lub ntsws thiab yog ib qho teeb meem kev noj qab haus huv thoob ntiaj teb cuam tshuam rau tib neeg thiab tib neeg.Hauv txoj kev tshawb no, tus qauv nas ntawm PAH raug ntxias los ntawm monocrotaline (MCT) tau ua tiav tiav.Cov mitochondrial proteins ntawm txhua pab pawg nas tau txiav txim los ntawm kev siv daim ntawv lo-free quantitative proteomic techniques.Raws li kev tsim kho thiab kev ua haujlwm zoo ntawm cov protein-protein sib cuam tshuam (PPI) tes hauj lwm, 19 nce-tswj mitochondrial genes thiab 123 down-regulated mitochondrial noob tau soj ntsuam hauv PAH nas.Tsis tas li ntawd, nyob rau hauv ib qho kev ywj pheej cohort dataset kev sim, cov txiaj ntsig tau pom tias 6 qhov kev tswj hwm mitochondrial genes thiab 3 down-regulated mitochondrial genes tau muaj qhov txawv txav hauv cov ntaub so ntswg ntawm PAH nas.Muaj peev xwm miRNA-targeted central mitochondrial genes tau kwv yees nyob rau theem transcriptome siv RNAInter database.Txoj kev tshawb no kuj tau txheeb xyuas bortezomib thiab carfilzomib ua cov tshuaj muaj peev xwm los kho PAH.Thaum kawg, txoj kev tshawb no nthuav tawm lub teeb tshiab ntawm biomarkers tseem ceeb thiab cov tswv yim kho mob rau PAHs.
Foregene
Cov ntaub ntawv hais txog cov khoom
RT Easy II (Master Premix rau Thawj Strand cDNA Synthesis Rau qPCR)
Yam khoom No.: RT-01021
Specification: 50 × 10 μL rxns
Tshooj npe: PTEN poob confers rhiab heev rau rapalogs nyob rau hauv ntshiab cell cell carcinoma
PIB: 10.1038/s41401-022-00862-1
Sijhawm tso tawm: 2022-2-14
Tus neeg sau kev koom tes: Department of Pharmacy, Nanfang Tsev Kho Mob, Southern Medical University, Guangzhou, Suav
Cov Lus Qhia: Rapalog yog ib qho allosteric mTORC1 inhibitor thiab cov tshuaj pom zoo rau cov kab mob hauv lub raum cell carcinoma (ccRCC).Kev tshawb fawb siv ntau tus neeg mob tau txais los ntawm ccRCC kab ntawm tes qhia tau tias PTEN-tsis muaj hlwb pom muaj qhov tsis txaus siab rau rapalogs.Hauv PTEN-tsis muaj ccRCC kab ntawm tes, Rapalogs inhibited cell proliferation los ntawm inducing G0 / G1 ntes tsis inducing apoptosis.Siv CRISPR/Cas9-tsim isogenic cell kab, txoj kev tshawb fawb tau lees paub lub koom haum ntawm PTEN deletion thiab Rapallo hypersensitivity.Hauv qhov sib piv, kev tshem tawm ntawm VHL lossis chromatin-hloov cov noob (PBRM1, SETD2, BAP1, lossis KDM5C) tsis cuam tshuam cov lus teb ntawm tes rau rapalogs.Ectopic qhia ntawm ib qho activated mTOR mutant (C1483F) tau pom tias tiv thaiv PTEN-induced cell loj hlob inhibition, thaum qhia txog cov tshuaj tiv thaiv mTOR mutant (A2034V) tso cai rau PTEN-tsis muaj ccRCC hlwb kom dim ntawm kev loj hlob-txhawj xeeb los ntawm rapalogs.PTEN-tsis muaj ccRCC hlwb tau nkag siab ntau dua rau cov teebmeem inhibitory ntawm temsirolimus ntawm cell migration thiab qog loj hlob nyob rau hauv zebrafish thiab xenograft nas.Cov kev tshawb fawb tau pom tias kev tshem tawm PTEN yog txuam nrog rapallo rhiab heev thiab tuaj yeem siv los ua tus cim rau kev xaiv rapallo therapy hauv ccRCC cov neeg mob.
Foregene
Cov ntaub ntawv hais txog cov khoom
Kab lus lub npe: Dynamic mechanism ntawm microbiota ntawm high-salinity organic wastewater nrog ntsev-tiv taus poov xab thiab nws daim ntawv thov
PIB: 10.1016/j.jece.2022.107377
Sijhawm tso tawm: 2022-2-12
Sau chav tsev: Lub Tsev Kawm Ntawv ntawm Lub Neej Sciences, Jiangxi Normal University
Lus Nug: High salinity organic wastewater yog cov dej khib nyiab uas muaj cov khoom siv nyuaj, biodegradability tsis zoo thiab kev kho biochemical nyuaj.Txhawm rau nthuav tawm cov txheej txheem hauv nruab nrab ntawm cov zej zog microbial hauv kev kho cov dej salinity organic khib nyiab los ntawm cov poov xab ntsev-tiv taus, kev tshawb fawb txog tus cwj pwm ntawm cov zej zog microbial thiab cov xwm txheej ib puag ncig tau ua tiav.Kev tshem tawm cov nqi ntawm cov tshuaj oxygen xav tau, NH3-H thiab tag nrho cov nitrogen tau txhim kho tau zoo nyob rau hauv kev sim ntsuas WWTP.High-throughput sequencing cov txiaj ntsig tau pom tias biofortification cuam tshuam rau cov qauv hauv zej zog microbial.Nyob rau theem phylum, pawg Proteobacteria thiab Ascomycota predominate, thaum nyob rau theem genus Paracoccus thiab Meyeroi pawg predominate.Meyerella plays lub luag haujlwm tseem ceeb hauv kev kho cov dej qab ntsev ntau hauv cov dej khib nyiab, uas tej zaum yuav yog qhov laj thawj tseem ceeb rau kev txhim kho cov pa phem tshem tawm.Tsis tas li ntawd, pH, yaj oxygen, thiab lub ntim muaj zog yog qhov tseem ceeb cuam tshuam rau kev vam meej ntawm cov zej zog microbial thaum lub sij hawm bioaugmentation, txawm li cas los xij, Meyerrotheca abundance tsis cuam tshuam los ntawm cov pa phem ntau.Txoj kev tshawb no tau qhia txog kev hloov pauv hloov pauv thiab kev ua haujlwm ntawm cov kab mob hauv lub sijhawm bioaugmentation, nrog rau kev sib raug zoo ntawm cov zej zog microbial thiab ib puag ncig, tso lub hauv paus ruaj khov rau kev kho mob tom ntej ntawm high-concentration thiab high-ntsev dej khib nyiab.
Foregene
Cov ntaub ntawv hais txog cov khoom
Nqe Lus Nug: Multi-Omics Kev Ntsuam Xyuas Tom Qab Kev Tswj Xyuas Qhov Ncauj ntawm Bacteroides fragilis hauv Qaib.
DOI: 10.3389/fmicb.2022.846011 ib.
Sijhawm tso tawm: 2022-2-16
Sau Affiliation: Sichuan Key Laboratory of Agricultural thiab Animal Genetic Resources Development thiab Innovation
Abstract: Lub cev xeeb tub ntawm qaib yog ib qho tseem ceeb rau lub qe tsim.Kev sib raug zoo ntawm qhov chaw mos thiab ib puag ncig sab nraud tuaj yeem ua rau muaj kev cuam tshuam ntawm ntau yam kab mob pathogenic, cuam tshuam rau sab hauv thiab sab nraud zoo ntawm cov qe, thiab txawm tias nce cov neeg tuag thiab ua rau kev poob nyiaj txiag.Nyob rau hauv xyoo tas los no, probiotics tau coj cov txiaj ntsig kev lag luam rau cov tsiaj nyeg thiab nqaij qaib ntau lawm ua lwm txoj rau tshuaj tua kab mob.Cov teebmeem ntawm qhov chaw mos ntawm B. fragilis ntawm nqaij qaib cloacal microbiota, qhov chaw mos transcriptome thiab metabolome tau tshawb xyuas los soj ntsuam cov txiaj ntsig zoo ntawm B. fragilis.Cov txiaj ntsig tau pom tias B. fragilis kev kho mob cuam tshuam rau microbial muaj pes tsawg leeg ntawm cloaca.Kev txheeb xyuas cov ntaub ntawv pov thawj pom tau tias cov tshuaj tiv thaiv kab mob CCN3, HAS2, thiab RICTOR tau tswj hwm, thiab cov noob inflammatory EDNRB, TOX, thiab NKX2-3 tau qis-tswj, thiab DEGs kuj tau ua kom muaj txiaj ntsig zoo hauv kev tswj kev mob, cellular metabolism, thiab synaptic teb txoj hauv kev.Tsis tas li ntawd, qhov sib txawv metabolites feem ntau cuam tshuam nrog steroid hormone biosynthesis, unsaturated fatty acid biosynthesis, thiab arachidonic acid metabolism, thiab cov kev tshawb fawb txheeb xyuas cov koom haum ntawm cov metabolites tshwj xeeb thiab cov noob.Nyob rau hauv xaus, txoj kev tshawb no muab ib tug theoretical hauv paus rau daim ntawv thov ntawm B. fragilis raws li ib tug muaj peev xwm probiotic nyob rau hauv cov tsiaj txhu thiab nqaij qaib ntau lawm.
Foregene
Cov ntaub ntawv hais txog cov khoom
RT Easy II (Master Premix rau thawj strand cDNA synthesis rau qPCR)
Yam khoom: RT-01031
Specification: 25 × 20 μL rxns
Kab lus lub npe: Ntau haiv neeg ntawm Echinococcus granulosus sensu lato hauv Suav teb: Kev tshawb fawb txog kab mob thiab kev tshuaj xyuas
DOI: 10.1111/ib.14469
Sijhawm tso tawm: 2022-2-9
Sau Affiliation: Sichuan Key Laboratory of Agricultural thiab Animal Genetic Resources Development thiab Innovation
Cov Lus Qhia: Cystic echinococcosis (CE) yog ib qho kab mob uas tsis saib xyuas zoonotic tshwm sim los ntawm Echinococcus granulosus thiab tseem yog ib qho teeb meem loj thoob ntiaj teb kev noj qab haus huv.Lub npe hu ua genotypes ntawm Echinococcus granulosus uas tsis yog G4 tau raug txheeb xyuas nyob rau hauv Suav teb, tshwj xeeb tshaj yog Qinghai-Tibet Plateau, thiab lawv cov caj ces muaj ntau haiv neeg nyob hauv cheeb tsam ntawm lub ntiaj teb no.Raws li kev tshuaj xyuas, cov noob caj noob ces ntawm E. granulosa hauv kuv lub tebchaws yog raws li hauv qab no: E. granulosa (G1, G3), 98.3%;Echinococcus intermedius (G5), 0.1%;Echinococcus intermedius (G6, G7), 1.4%;thiab Canada Echinococcus (G8, G10), 0.2%.Tshwj xeeb, tus kab mob G1 yog 97.7% thiab yog tus cwj pwm los ntawm ntau tus tswv tsev thiab thaj chaw faib khoom.Cov txiaj ntsig ntawm kev kis kab mob tau pom tias muaj qhov ruaj khov thiab zoo-grained E. coli noob muaj nyob hauv yaj thiab yak los ntawm peb lub xeev CE high-endemic (Xinjiang, Sichuan, thiab Qinghai).Yaj (287/406, 70.7%) muaj feem ntau ntawm fertile cysts tshaj yak (28/184, 15.2%).Hauv 29 xyoo dhau los, muaj 51 Echinococcus granulosus cox1 haplotypes hauv Suav teb.Cov poj koob yawm txwv haplotype (Hap_2) tseem yog cov haplotypes ntau tshaj plaws, 12 feem ntau haplotypes yog qhov kawg, thiab 9 qhov tshiab tshaj tawm haplotypes tau txheeb xyuas thaum lub sijhawm tshawb fawb.Cov kev tshawb pom qhia tias qhov yuav tsum tau txhaj tshuaj tiv thaiv yaj thiab EG95 txhaj tshuaj tiv thaiv kab mob ntawm yaks zoo sib xws rau cov xwm txheej tam sim no.
Foregene
Cov ntaub ntawv hais txog cov khoom
Hu rau:
Maggie |Kev txhim kho kev lag luam
Foregene Co., Ltd
M: +86-15281067355
URL: www.foreivd.com
Post lub sij hawm: Apr-08-2022
