Ntau tshaj li ib nrab ntawm 2022, tuaj saib seb cov ntawv tau qhab nia siab tau tshaj tawm los ntawm Foeregene !
01
PIB: 17.694
Luam tawm los ntawm: Thawj Tsev Kho Mob, Sun Yat-sen University
Cov ntsiab lus tseem ceeb: Esophageal squamous cell carcinoma (ESCC) yog lub ntsiab subtype ntawm mob qog noj ntshav esophageal.Kev txheeb xyuas cov hom phiaj kho tau zoo yog qhov tseem ceeb rau kev kho kom zoo ntawm ESCC.Qee qhov kev tshawb fawb tau pom tias RNA mismodification tuaj yeem txhawb kev qhia thiab kev txhais lus ntawm cov qog nqaij hlav qog noj ntshav nrog mRNAs, tab sis cov txheej txheem molecular tseem tsis meej.Txoj kev tshawb no tau pom tias tRNA m7G methyltransferase-txog cov proteins uas cuam tshuam rau METTL1 thiab WDR4 tau nce ntau hauv ESCC cov ntaub so ntswg thiab pab txhawb rau qhov tsis zoo ntawm ESCC.Txij thaum ntawd los, METTL1 thiab WDR4-hais txog kev tshawb fawb txog noob caj noob ces hauv ESCC qauv nas tau lees paub tias qhov kev ua kom zoo dua ntawm tRNA m7G methyltransferase ua rau muaj kev tswj hwm ntawm kev qhia ntawm ob cov proteins, uas ua rau txhawb kev loj hlob ntawm ESCC hlwb.Txoj kev tshawb no qhia txog qhov tseem ceeb ntawm kev ua haujlwm oncogenic ntawm kev hloov kho tRNA m7G tsis raug cai hauv ESCC thiab qhia tias kev tsom mus rau METTL1 thiab nws txoj hauv kev taw qhia hauv qab yuav ua rau cov phiaj xwm kho mob rau ESCC txoj kev kho.
Cov khoom pabcuam:
Mouse Tail Direct PCR Cov Khoom Siv Foregene#TP-01333
Original link:
https://www.nature.com/articles/s41467-022-29125-7
02
PIB: 14.903
Luam tawm los ntawm: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
Cov ntsiab lus tseem ceeb:
Nrog rau kev tsim cov tshuab hluavtaws, mRNA tau dhau los ua cov chav kawm tshiab ntawm cov tshuaj kho mob.Txawm li cas los xij, ua kom tau txais txiaj ntsig zoo ntawm kev xa tawm ntawm cov tshuaj mRNA tseem nyuaj vim qhov rhiab heev ntawm mRNA rau RNases.Txoj kev tshawb no nthuav tawm txoj kev xa khoom yooj yim ntawm polyphenol-conjugated nanostructures uas tuaj yeem xa tau zoo IL-10 mRNA hauv vivo.Tom qab siv cov nanostructure no los xa cov tshuaj mRNA, IL-10 qib tau tshwj xeeb nce-tswj, muaj txiaj ntsig zoo inhibit qhov kev qhia ntawm cov kab mob inflammatory, txhawb kev kho mucosal, tiv thaiv colonic epithelial hlwb los ntawm apoptosis, thiab inhibiting dextran sodium sulfate-induced mob thiab mob me me Lub murine colitis qauv muaj qhov tseem ceeb rau kev kho mob caj dab.
Cov khoom pabcuam:
Tsiaj Tag Nrho RNA Isolation Kit Foregene#RE-03011
Original link:
03
PIB: 12.499
Luam tawm los ntawm: Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University
Cov ntsiab lus tseem ceeb:
Oxidative stress ntawm phev yog ib qho tseem ceeb uas ua rau txiv neej infertility, yog li nws yog ib qho ua tau thiab muaj txiaj ntsig kev xaiv los tsim cov txiv neej infertility tsiaj qauv los ntawm kev kho cov tshuaj antioxidant hauv lub hom phiaj.Txawm li cas los xij, txiv neej kab mob ntawm tes tshwj xeeb antioxidant mechanisms tsis tau qhia meej.Txoj kev tshawb no tau lees paub tias LanCL1 noob yog cov tshuaj antioxidant tshwj xeeb hauv cov txiv neej cov kab mob hlwb, thiab nws cov lus qhia tau txo qis lossis cuam tshuam nrog tib neeg txiv neej infertility.Txiv neej nas tsis txaus nyob rau hauv LanCL1 noob pom cov phev oxidative puas thiab impaired fertility.Nyob rau hauv tus txheej txheem ntawm phev sib txawv ntawm cov kab mob hlwb, thaum lub oxidation nyiam tshwm sim, transcription factor-specific protein 1 (SP1) yuav tswj cov kev qhia ntawm LanCL1 noob, yog li inhibiting oxidation txheej txheem ntawm phev.Txoj kev tshawb no qhia tau hais tias SP1-LanCL1 txoj hauv kev ua lub luag haujlwm tseem ceeb hauv kev tswj cov qe ntshav hauv tsev thiab cov txiv neej fertility sib kho los ntawm redox tshuav nyiaj li cas, thiab qhia tias LanCL1-hloov nas muaj cov ntawv thov zoo li tsiaj qauv ntawm txiv neej infertility.
Khoom pab:
Mouse Tail DNA Mini Cov Khoom Siv Foregene#DE-05211
Original Link:
http://europepmc.org/article/MED/35469022
Mouse Tail Direct PCR Cov Khoom Siv
◮ Tsis tas yuav siv sijhawm ntev thiab kim kho DNA purification.
◮ Cov qauv xav tau me me, tsuas yog nqa ib lub noob xwb.
◮ Tsis muaj kev kho tshwj xeeb xws li kev sib tsoo thiab kev sib tsoo, thiab kev ua haujlwm yooj yim.
◮ Qhov kev ua kom zoo ntawm PCR ua rau PCR muaj qhov tshwj xeeb dua thiab muaj zog ua siab ntev rau PCR cov tshuaj tiv thaiv.
Tsiaj Tag Nrho RNA Isolation Kit
◮ Tsis tas yuav txhawj txog RNA degradation.Tag nrho cov kab ke yog RNase-Free.
◮ Ua kom muaj txiaj ntsig zoo tshem tawm DNA siv DNA-Tshuaj Kab.
◮ Tshem tawm DNA yam tsis tau ntxiv DNase.
◮ Yooj yim-txhua yam haujlwm ua tiav ntawm chav tsev kub.
◮ Ceev—ua haujlwm tuaj yeem ua tiav hauv 30 feeb.
◮Safe — tsis muaj cov organic reagent siv.
◮High purity-OD260/280≈1.8-2.1.
Nas Tail DNA Mini Cov Khoom Siv
◮Tsis muaj RNase contamination:DNA-Tsuas Kem muab los ntawm cov khoom siv ua rau nws tuaj yeem tshem RNA los ntawm genomic DNA yam tsis tau ntxiv RNase thaum lub sij hawm sim, tiv thaiv lub chaw soj nstuam los ntawm exogenous RNase.
◮Ceev ceev:Foregene Protease muaj kev ua haujlwm siab dua li cov protease zoo sib xws, thiab zom cov ntaub so ntswg sai;kev ua haujlwm yog yooj yim, thiab cov genomic DNA rho tawm haujlwm tuaj yeem ua tiav hauv 20-80 feeb.
◮Yooj yim:Lub centrifugation yog ua nyob rau hauv chav tsev kub, thiab tsis tas yuav tsum tau rau 4 ° C low-temperature centrifugation los yog ethanol nag lossis daus ntawm DNA.
◮Kev nyab xeeb:Tsis muaj cov organic reagent extraction yog yuav tsum tau.
◮High quality:Cov genomic DNA uas tau muab rho tawm muaj cov tawg loj, tsis muaj RNA, tsis muaj RNase, thiab cov ntsiab lus tsis tshua muaj ion, uas tuaj yeem ua tau raws li qhov yuav tsum tau muaj ntawm ntau yam kev sim.
◮Micro-elution system:Nws tuaj yeem ua kom cov concentration ntawm genomic DNA, uas yooj yim rau kev tshawb nrhiav los yog kev sim.
Post lub sij hawm: Sep-13-2022
