Cov neeg siv khoom ntawm Lub Tsev Kawm Ntawv Kev Tshawb Fawb Txog Lub Neej, Sichuan University tau luam tawm cov ntaub ntawv tau qhab nia siab siv Foregene cov khoom, nrog rau qhov cuam tshuam ntawm 17.848.

Tsis ntev los no, pab pawg Song Xu los ntawm Lub Tsev Kawm Ntawv Kev Tshawb Fawb Txog Lub Neej ntawm Sichuan University tau luam tawm daim ntawv npog npeCoagulation yam VII, IX thiab X yog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob Gram-negative Bacteria hauv Cell Research.

Cell Research yog ib phau ntawv xov xwm thoob ntiaj teb sib koom ua ke los ntawm Suav Academy ntawm Kev Tshawb Fawb thiab British Nature Publishing Group, uas yog qhov muaj txiaj ntsig zoo hauv ntiaj teb kev kawm.

Thaum tsab xov xwm no tau tshaj tawm, nws tam sim ntawd ua rau muaj kev xav hauv kev kawm.Txog tam sim no, cov txiaj ntsig kev tshawb fawb tau txais los ntawm ntau lub xov xwm xws li Xinhua News Agency, World Wide Web, Phoenix Net, Southern Metropolis Daily,Biological Valley, British Daily Mail, American Daily Science, EurekAlert1!, Springer Nature, Phys.org, thiab lwm yam., BioMedCentral thiab lwm cov ntawv xov xwm muaj npe nrov muaj cov ntaub ntawv nthuav dav, thiab thoob ntiaj teb kev saib xyuas rau qhov kev tshawb fawb no tseem loj tuaj.

Tsab xov xwm tau taw qhia tias peb coagulation yam VII, IX thiab X uas ua lub luag haujlwm hauv kev pib ntawm coagulation cascade yog ib hom tshiab ntawm endogenous host antibacterial protein, uas yog, coagulation yam VII, IX thiab X muaj lub luag haujlwm tseem ceeb hauv cov txheej txheem coagulation.Nws kuj tseem tuaj yeem tiv thaiv cov kab mob Gram-tsis zoo, suav nrog cov kab mob "super" tiv taus xws li Pseudomonas aeruginosa thiab Acinetobacter baumannii.

Song Xu, tus sau cov lus no, hais tias: "Yav dhau los, feem ntau ntseeg tau tias coagulation yam tuaj yeem ua rau thrombosis, tab sis txoj kev tshawb no tau qhia tias coagulation yam tseem muaj qhov tshwj xeeb ntawm kev ua kom tsis muaj menyuam.Nov yog thawj qhov kev tshawb pom hauv tsev thiab txawv teb chaws”

Kev tshawb fawb keeb kwm

Raws li peb txhua tus paub, cov kab mob tiv thaiv tau dhau los ua teeb meem kev noj qab haus huv rau pej xeem thoob ntiaj teb.Cov ntaub ntawv ntsig txog taw qhia tias ze li ntawm 1 lab tus tib neeg tuag los ntawm cov kab mob tiv thaiv kab mob tshuaj tiv thaiv thoob ntiaj teb txhua xyoo.Yog tias tsis muaj kev daws teeb meem zoo dua, cov neeg tuag txhua xyoo los ntawm 2050 yuav yog 10 lab.

Kev tsim txom ntawm cov tshuaj tua kab mob, ua ke nrog kev muaj peev xwm hloov pauv tau zoo ntawm cov kab mob, tau ua rau qee cov kab mob pathogenic uas tuaj yeem tua los ntawm cov tshuaj tua kab mob ua tshuaj tiv thaiv, dhau los ua "cov kab mob super".

Tsis tas li ntawd, piv nrog cov kab mob Gram-positive (Gram +), cov kab mob tsis zoo (Gram-) yog qhov nyuaj rau tua vim muaj cov kab mob sab nrauv (lub ntsiab lus tseem ceeb yog LPS, alias endotoxin, lipopolysaccharide).Lub sab nrauv membrane yog ib lub hnab ntawv uas muaj nyob rau hauv lub cell membrane, ib tug nyias cell phab ntsa thiab ib tug txheej cell membrane.

Tshawb nrhiav keeb kwm

Pab pawg Song Xu tau kawm txog cov txiaj ntsig ntawm coagulation yam ntawm kev kho mob qog nqaij hlav, tab sis xyoo 2009, nws tau tshawb pom tias qhov coagulation yam tuaj yeem tua cov kab mob.Txhawm rau piav qhia cov kab mob bactericidal ntawm coagulation yam, qhov project tau 10 xyoo txij thaum pib ntawm kev tshawb fawb mus rau kev tshaj tawm ntawm daim ntawv.

Tsis pom kev

Xyoo 2009, cov kws tshawb fawb tau tshawb pom tias qhov coagulation yam VII tuaj yeem tawm tsam Escherichia coli ntawm ntau tshaj li kaum ob coagulation yam.

Escherichia coli belongs rau Gram-negative kab mob hauv cov kab mob.Cov kab mob no yog qhov nyuaj rau kev daws, vim tias lawv cov hlwb muaj cov kab mob hauv lub cev, cov phab ntsa nyias nyias thiab cov cell sab nraud.Lub hnab ntawv tuaj yeem khaws cov tshuaj tawm thiab tiv thaiv cov kab mob los ntawm "kev nkag mus".

Qhia qhov kev xav

Coagulation yam yog ib pawg ntawm cov proteins hauv cov ntshav uas koom nrog hauv cov ntshav txhaws.Thaum tib neeg lub cev raug mob ua rau los ntshav, ntau yam coagulation yam yog qhib los ntawm kauj ruam los tsim cov fibrin filaments, uas kaw lub qhov txhab ua ke nrog platelets.Yog tias tsis muaj ib lossis ob peb coagulation yam tsis muaj, coagulation teeb meem yuav tshwm sim.

Cov kws tshawb fawb tau pom tias cov neeg mob coagulopathy feem ntau ua rau cov kab mob xws li sepsis thiab mob ntsws.Qhov kev sib txuas no ua rau lawv xav tias coagulation yam tseem ceeb yuav tsis tsuas yog ua lub luag haujlwm tseem ceeb hauv cov txheej txheem coagulation, tab sis kuj tseem tuaj yeem muaj kev tiv thaiv kab mob.

Kev kawm tob

Txhawm rau tshawb xyuas seb coagulation yam tuaj yeem cuam tshuam nrog ntau yam kab mob Gram-negative, cov kws tshawb fawb tau pib kawm nws cov tshuaj tua kab mob hauv qhov tob.Lawv pom tias coagulation factor VII thiab cov yam ntxwv zoo sib xws IX thiab factor X, peb cov proteins no tuaj yeem tawg los ntawm lub hnab ntawv khoom ntawm cov kab mob gram-tsis zoo.

Ntau cov tshuaj tua kab mob uas twb muaj lawm tsom cov cell metabolism lossis cell membranes, tab sis peb cov coagulation yam muaj ntau hom kev ua.Lawv tuaj yeem hydrolyze LPS, cov khoom tseem ceeb ntawm cov kab mob sab nrauv.Poob LPS ua rau nws nyuaj rau cov kab mob Gram-negative kom ciaj sia.

Mus ntxiv

Pab neeg tshawb fawb ntxiv tshawb xyuas lub tshuab thiab pom tiascov coagulation factor protein ua rau cov kab mob los ntawm nws lub teeb saw txuas, thaum lub zog saw hnyav tsis muaj cov nyhuv antibacterial.

Hauv chav kuaj kab lis kev cai ib puag ncig, cov kws tshawb fawb tau pom meej tias tom qab ntxiv cov coagulation los yog nws cov khoom siv hauv lub teeb, cov kab mob hauv lub hnab ntawv raug puas tsuaj ua ntej, thiab tom qab ntawd hauv 4 teev, tag nrho cov kab mob ntawm tes yuav luag tag nrho.

Ntxiv qhov tseem ceeb VII lub teeb saw txuas rau kab lis kev cai Escherichia coli,

Cov kab mob sab nraud ntawm daim nyias nyias yog puas, cov hlwb raug puas tsuaj

Tsis yog Escherichia coli nkaus xwb, tab sis qee qhov lwm cov kab mob Gram-negative kuaj tau "tshem tawm", suav nrog Pseudomonas aeruginosa thiab Acinetobacter baumannii.Ob leeg ntawm cov kab mob no tau teev tseg los ntawm Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb (WHO) ua 12 cov kab mob phem tshaj plaws rau tib neeg kev noj qab haus huv vim lawv cov tshuaj tiv thaiv.

Kev soj ntsuam xyuas

Cov kev sim tsiaj hauv qab no ntxiv txheeb xyuas qhov ua tau zoo ntawm cov kab mob hauv lub cev tiv thaiv kab mob super.

Cov kws tshawb nrhiav inoculated nas nrog ntau cov tshuaj tiv thaiv Pseudomonas aeruginosa lossis Acinetobacter baumannii.Tom qab txhaj tshuaj ntau ntawm qhov tseem ceeb VII lub teeb saw, cov nas muaj sia nyob;thaum cov nas nyob hauv pab pawg tswj hwm tau txhaj tshuaj saline ib txwm muaj 24 Tag nrho cov neeg tuag ntawm tus kab mob tom qab teev.

Tom qab kis tau tus kab mob super, infusion ntawm yam VII lub teeb saw

Nws tuaj yeem ua lub luag haujlwm tiv thaiv thiab txhim kho kev muaj sia nyob ntawm cov nas

Qhov tseem ceeb

Tam sim no, tsis muaj tshuaj tua kab mob yog paub tias ua tau zoo los ntawm hydrolyzing LPS.

Qhia meej txog cov kab mob tua kab mob raws li LPS hydrolysis thiab cov yam ntxwv ntawm cov kab mob ntawm cov kab mob coagulation, ua ke nrog kev muaj peev xwm tsim cov coagulation yam tseem ceeb ntawm qhov loj ntawm tus nqi qis, tuaj yeem muab cov tswv yim tshiab tsim nyog los tawm tsam cov kab mob Gram-tsis zoo tshuaj tiv thaiv kab mob thaum muaj xwm txheej ceev rau pej xeem kev noj qab haus huv teeb meem tshwm sim.

Tsis tas li ntawd, txoj haujlwm no tseem muaj kev thov dav dav hauv kev kho mob.Tam sim no, tsis muaj cov tshuaj tua kab mob uas paub tias muaj txiaj ntsig los ntawm hydrolyzing LPS.Kev sib xyaw cov tshuaj tua kab mob ntawm FVII, FIX, thiab FX tiv thaiv LPS thiab cov nqi qis qis, nws xav tias yuav tsim cov tshuaj tshiab tiv thaiv kab mob "super bacteria".

Ntsiab lus extension

Txawm hais tias tib neeg paub ntau lub npe "cov kab mob super", lawv cov lus raug yuav tsum yog "cov kab mob ntau yam tshuaj tiv thaiv", uas yog hais txog ib hom kab mob uas tiv taus ntau yam tshuaj tua kab mob.

Raws li tau hais ua ntej lawm, tam sim no kev tiv thaiv ntawm cov kab mob no feem ntau yog vim kev siv tsis tsim nyog lossis txawm tias siv tshuaj tua kab mob.Piv txwv li, kev siv ntau zaus ntawm cov tshuaj tua kab mob broad-spectrum hauv kev kho cov kab mob ua pa.

Kab mob ua pa yog ib yam kab mob uas peb txhua tus paub.Raws li kev txheeb cais, txhua tus menyuam yaus kis tus kabmob li 6 txog 9 zaug hauv ib xyoos, thiab cov tub ntxhais hluas thiab cov neeg laus kis tau li 2 txog 4 zaug hauv ib xyoos.

Vim tias kab mob ua pa feem ntau yog lub chaw haujlwm xwm txheej ceev, qhov nyuaj tshaj plaws rau cov kws kho mob xwm txheej ceev thaum ntsib cov neeg mob yog tias lawv tsis tuaj yeem tau txais cov ntaub ntawv kab mob hauv lub sijhawm luv.Yog li, kev lag luam ntawm kev kuaj kab mob ua rau cov kws kho mob yuav tsum tau siv tshuaj tua kab mob dav dav (uas tuaj yeem ua tau zoo).Rau ntau hom kab mob).

Nws yog qhov "kev nthuav tawm lub vas loj" ntawm cov tshuaj uas tau ua rau muaj teeb meem loj zuj zus ntxiv ntawm cov kab mob kis tau cov tshuaj tiv thaiv.Vim hais tias thaum feem ntau ntawm cov kab mob rhiab heev raug tua tsis tu ncua, cov tshuaj tiv thaiv kab mob yuav ua rau ntau ntxiv los hloov cov kab mob rhiab heev, thiab cov kab mob tiv thaiv cov tshuaj yuav nce ntxiv.

Yog li ntawd, yog tias daim ntawv qhia txog kev kuaj kab mob muaj tseeb tuaj yeem tau txais hauv lub sijhawm luv luv los qhia cov kws kho mob hauv kev sau cov tshuaj zoo, kev siv cov tshuaj tua kab mob dav dav tuaj yeem txo qis, yog li txo qhov teeb meem ntawm cov kab mob.

Tau ntsib nrog qhov teeb meem no, Fuji pab pawg tshawb fawb tshawb fawb tau teeb tsa los tsim 15-khoom ua pa tiv thaiv kab mob.

Cov khoom siv no tau txais kev sib xyaw ua ke ntawm Direct PCR thiab multiplex PCR thev naus laus zis, uas tuaj yeem ntes Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Haemophilus influenzae thiab lwm yam 15 kab mob ua pa qis hauv cov hnoos qeev li ntawm 1 teev.Cov kab mob pathogenic tuaj yeem paub qhov txawv ntawm cov kab mob colonizing (cov kab mob ib txwm muaj) thiab cov kab mob pathogenic.Kuv ntseeg tias nws yuav tsum yog ib qho cuab yeej zoo los pab cov kws kho mob hauv kev siv tshuaj zoo.

Nyob rau hauv lub ntsej muag ntawm "cov kab mob super", pej xeem yeeb ncuab ntawm tag nrho cov tib neeg, noob neej yeej tsis coj nws maj mam.Hauv kev tshawb fawb txog kev ua neej, tseem muaj ntau tus kws tshawb fawb xws li Song Xu pab neeg uas ua haujlwm hnyav los tshawb nrhiav thiab ua haujlwm ntsiag to ntawm txoj kev mus nrhiav "cov kab mob super" cov kev daws teeb meem.

Ntawm no, sawv cev ntawm cov phooj ywg lom neeg thiab cov neeg tau txais txiaj ntsig, Fortune Biotech xav qhia nws txoj kev hwm siab tshaj plaws rau txhua tus kws tshawb fawb uas tau mob siab rau lawv txoj kev siv zog thiab tawm hws rau qhov no, thiab tseem thov Vajtswv kom tib neeg tuaj yeem kov yeej "cov kab mob super" sai li sai tau thiab muaj kev nyab xeeb thiab noj qab haus huv lub neej.ib puag ncig.