Qhov chaw txhais lus: WuXi AppTec pab pawg editor

Hauv Guangzhou, Tuam Tshoj, tub ceev xwm lub luag haujlwm pabcuam kev tshawb nrhiav kabmob kis tau tshaj tawm cov yeeb yaj kiab soj ntsuam: Hauv tib lub tsev noj mov, ob leeg tau taug kev mus rau hauv chav dej ib tom qab tsis muaj kev sib cuag ntawm lub cev.Tsuas yog 14 vib nas this ntawm kev sib koom ua ke tau tso cai rau tus kab mob tshiab tshiab los nrhiav txoj hauv kev, ua kom tiav kev sib kis.

WuXi AppTec cov ntsiab lus pab pawg ua haujlwm

Hauv tebchaws Australia nyob rau sab qab teb hemisphere, tib neeg kuj xav tsis thoob thaum pom qhov zoo sib xws "kev kis mob tam sim".Thaum cov kws saib xyuas kev noj qab haus huv hauv New South Wales tau taug qab cov xwm txheej, lawv pom tias tus neeg muaj tus kabmob thiab tsawg kawg peb tus neegtsuas yog "dhau los ntawm" sab nraum lub khw lossis khw kas fes, nkag mus rau tib qhov chaw sai sai, thiab tus kab mob ua rau kis tus kab mob.

Cov txiaj ntsig ntawm tus kab mob genome sequencing ntawm cov qauv ntawm cov xwm txheej no tau pom tias tus kabmob tshiab noua rau tus kabmob kis tau los ntawm Delta mutant hom, uas yog tus kabmob tshiab tus kabmob mutant uas tau pom thawj zaug hauv Is Nrias teb thaum Lub Kaum Hli 2020.Tus kws tshaj lij Zhong Nanshan kuj tau taw qhia hauv kev sib tham hauv xov xwm tsis ntev los no tias "lub delta strain muaj lub nra hnyav,cov pa exhaled yog tshuaj lom thiab kis tau zoo heev", yog li cov qauv nruj dua yuav tsum tau txhais "cov neeg nyob ze" ...

Ravage lub ntiaj teb no

Lub Plaub Hlis thiab Tsib Hlis 2021, muaj nthwv dej hnyav ntawm kev sib kis hauv Is Nrias teb.Raws li cov ntaub ntawv tshaj tawm los ntawm Indian Ministry of Health,tus naj npawb ntawm cov mob tshiab tau lees paub hauv ib hnub tau tshaj 400,000 nyob rau ib zaug!Txawm hais tias muaj kev sib sau loj thiab lwm yam hauv qab nws, qhov tseeb tsis txaus ntseeg yog tias tus naj npawb ntawm cov neeg kis tus kab mob Delta mutant tau nce sai.

Sab nraum Is Nrias teb, los ntawm Nepal mus rau Southeast Asia, mus rau thaj chaw loj dua thoob ntiaj teb, tus kab mob Delta mutant kuj kis tau ob lub hlis dhau los.

“Delta variant yog qhov sib kis tau zoo tshaj plaws nyob rau tam sim no.Nws tau pom nyob rau hauv 85 lub teb chaws / cheeb tsam thiab tau kis sai heev ntawm cov neeg tsis tau txhaj tshuaj.” Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb Tus Thawj Coj-Dr. Tan Desai thaum Lub Rau Hli 25 Hais ntawm lub rooj sib tham xov xwm.

Dr. Tan Desai, Tus Thawj Coj-General ntawm Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb |ITU Duab los ntawm Geneva, Switzerland, CC BY 2.0, ntawm Wikimedia Commons)

Thawj kis ntawm tus kab mob Delta tau kuaj pom hauv tebchaws United Kingdom thaum nruab nrab Lub Plaub Hlis.Lub sijhawm ntawd, tom qab ob peb lub hlis ntawm "kev thaiv", nrog rau kev nce qib ntawm kev txhaj tshuaj tiv thaiv, tus naj npawb ntawm cov kab mob, kev mus pw hauv tsev kho mob, thiab kev tuag tag nrho poob qis, thiab kev sib kis zoo li yuav txhim kho.

Txawm li cas los xij, Delta mutant hom kab mob sai sai ua rau lub nthwv dej thib peb ntawm cov kab mob sib kis hauv UK, thiab cov neeg mob tshiab nyob rau ib hnub tau tshaj 8,700.Tus kab mob kis tau sai heev ntawm cov neeg uas tsis tau txhaj tshuaj tiv thaiv, yuam UK ncua nws txoj kev npaj rov qhib dua.Qhov tseeb,Tam sim no Delta mutant strain tau hloov Alpha mutant hom (uas yog, B.1.1.7 mutant strain) thawj zaug pom nyob rau hauv UK, thiab tau dhau los ua qhov tseem ceeb tshaj plaws hauv zos tus kabmob tshiab.

Ntawm Tebchaws Asmeskas, qhov sib txawv ntawm Delta variants kuj ua rau muaj kev txhawj xeeb.Raws li cov qauv kev tshawb fawb hauv California,Tus naj npawb ntawm cov xwm txheej tshwm sim los ntawm Alpha variant strain, uas yav dhau los yog "mainstream", tau nqis los ntawm ntau dua 70% thaum lub Plaub Hlis lig mus txog 42% thaum lub Rau Hli lig, thiab "nce" ntawm Delta variant yog lub luag haujlwm rau qhov no.Lub ntsiab yog vim li cas rau qhov kev hloov no.Tus thawj coj ntawm Teb Chaws Asmeskas Lub Chaw Tiv Thaiv thiab Tiv Thaiv Kab Mob (CDC) ceeb toom tias nyob rau ob peb lub lis piam tom ntej no, tus kab mob Delta tuaj yeem dhau los ua tus kab mob coronavirus tshiab loj hauv Tebchaws Meskas.

Qhov sib txawv ntawm COVID-19 hom kab mob mutant (Delta mutant hom yog ntsuab) |nextstrain.org)

Hauv Suav teb, ntxiv rau Guangzhou, cov neeg mob ntawm Delta mutant hom kuj tau pom nyob ze Shenzhen, Dongguan thiab lwm qhov chaw.Tib neeg lub taub hau ntawm kev tawm tsam nrog Delta mutant hom tau pib.

Tsis tsuas yog kev sib kis muaj zog dua

Txij li thaum muaj kev kis tus kabmob tshiab tshiab rau ntau tshaj ib xyoos, ntau hom kabmob mutant tau nyiam tshwj xeeb, suav nrog Alpha mutant hom uas tau pom thawj zaug hauv tebchaws United Kingdom thaum lub Cuaj Hlis 2020, thiab Beta mutant strain (B.1.351) uas tau lees paub thawj zaug hauv South Africa thaum lub Tsib Hlis 2020. , Thiab Lub Kaum Ib Hlis 2020.

Thaum Lub Tsib Hlis 11, Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb tau teev cov kab mob Delta mutant uas tau pom thawj zaug hauv Is Nrias teb ua plaub "variant hom kev txhawj xeeb” (VOC).Raws li kev txhais ntawm WHO, VOC txhais tau tias"Ntseeg lossis paub tseeb tias nws yuav ua rau muaj kev sib kis ntau ntxiv lossis muaj tshuaj lom;los yog nce lossis hloov hauv kev kho mob tshwm sim;los yog ua rau muaj kev hloov pauv hauv kev kuaj mob tam sim no, ntsuas kev kho mob, thiab kev siv tshuaj tiv thaiv.

Cov ntaub ntawv uas twb muaj lawm los ntawm cov tsev kawm ntawv xws li Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Tebchaws Askiv (PHE) qhia tiasLub peev xwm kis tau tus mob ntawm Delta variant strain yog 100% siab dua li ntawm thawj hom;piv rau Alpha variant strain uas tau ncig thoob ntiaj teb nyob rau hauv ib nrab xyoo tas los, Delta variant Lub peev xwm kis tau tus kab mob tseem muaj zog, qhov kis tau tus mob yog 60% siab dua.

Ntxiv rau qhov muaj peev xwm kis tau tus kab mob ntau ntxiv, Feng Zijian, tus kws tshawb fawb ntawm Tuam Tsev Saib Xyuas Kab Mob thiab Tiv Thaiv, tau hais thaum qhia txog cov xwm txheej tsis ntev los no ntawm cov kab mob tshiab hauv Guangzhou, Delta mutant strain "Lwm qhov tshwj xeeb yog tias lub sijhawm incubation lossis lub sijhawm dhau los yog luv luv-hauv lub sijhawm luv luv).Tsib lossis rau tiam dhau los hauv 10 hnub xwb.” Tsis tas li ntawd, PCR cov txiaj ntsig ntawm cov qauv ntawm cov neeg mob tau pom tias cov kab mob kis tau nce ntxiv, uas tseem ua rau muaj kev kis kab mob ntau dua.

Hauv tebchaws United Kingdom, qhov twg Delta variant tau suav txog 90% ntawm cov neeg mob, cov pov thawj ua ntej qhia tau hais tiaspiv nrog Alpha variant, cov neeg kis tus kab mob Delta variant yog yuav luag ob zaug uas yuav tau mus pw hauv tsev kho mob, uas txhais tau hais tias qhov kev pheej hmoo ntawm kev mus pw hauv tsev kho mob tau nce 100%.

Cov noob caj noob ces tseem ceeb tau nqa los ntawm ntau hom kab mob coronavirus tshiab mutant tus kab mob uas tam sim no muaj kev txhawj xeeb.Ntawm lawv, tus kab mob Delta mutant muaj 13 qhov kev hloov pauv caj ces tshwj xeeb piv nrog tus kab mob thawj zaug |WuXi AppTec Cov Ntsiab Lus Pab Pawg

Kev txiav txim los ntawm cov noob caj noob ces ntawm Delta mutant strain,nws muaj qee qhov kev hloov pauv tshwj xeeb hauv cov noob encoding cov protein ntau ntawm tus kabmob tshiab, uas tsis yog tsuas yog cuam tshuam tus kabmob kis tau tus kabmob, tab sis kuj tseem tuaj yeem ua rau kev tiv thaiv kabmob..Hauv lwm lo lus, neutralizing cov tshuaj tiv thaiv uas tsim tom qab kis kab mob los yog tshuaj tiv thaiv yav dhau los tuaj yeem ua rau lub peev xwm los khi rau Delta variant.

Qhov tseem ceeb ntawm cov tshuaj tiv thaiv

Nyob rau hauv lub ntsej muag ntawm kev ua phem rau Delta variant, cov tshuaj tiv thaiv uas twb muaj lawm puas tseem muaj kev tiv thaiv txaus?

"Nature" luam tawm ib daim ntawv tshawb fawb rau lub Rau Hli 10th.Cov txiaj ntsig ntawm kev sim tshuaj tiv thaiv kab mob tsis muaj peev xwm pom tau tiasob lossis plaub lub lis piam tom qab ua tiav kev txhaj tshuaj ntawm ob koob tshuaj mRNA neocorona tshuaj tiv thaiv BNT162b2, cov tshuaj tiv thaiv tsis zoo uas tsim tawm hauv tib neeg lub cev muaj txiaj ntsig zoo rau Delta.Cov kab mob tseem muaj qhov tseem ceeb inhibitory nyhuv.

Kev ua haujlwm nruab nrab ntawm cov tshuaj tiv thaiv cov ntshav tawm tsam tus kabmob tshiab tshiab thiab ntau hom kab mob sib kis nrog rau cov kab mob Delta |Cov ntaub ntawv [1]

Hauv kev teb rau ob hom kab mob loj, Delta thiab Alpha, ua rau cov tsos mob ntawm COVID-19, kev txhaj tshuaj tiv thaiv tau zoo npaum li cas, Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Tebchaws Askiv tau tshaj tawm cov txiaj ntsig ntawm kev tshawb fawb thoob ntiaj teb thaum lub Tsib Hlis.

Cov ntaub ntawv qhia tau hais tias txawm tias cov tshuaj tiv thaiv muaj kev tiv thaiv tsis muaj zog ntawm Delta hompiv rau Alpha hom, nws tseem tuaj yeem txo qhov kev pheej hmoo ntawm cov tsos mob tshiab.Tag nrho inoculated nrog ob txhaj tshuaj tiv thaiv mRNA, cov nyhuv tiv thaiv tuaj yeem ncav cuag 88%;Hauv qhov sib piv, qhov kev tiv thaiv tiv thaiv Alpha yog 93%.

Txoj kev tshawb no kuj pom tias yog tias tsuas yog txhaj tshuaj tiv thaiv ib zaug xwb, lub peev xwm los tiv thaiv tus kab mob mutant yuav txo qis.Peb lub lis piam tom qab thawj koob txhaj tshuaj, ob qhov tshuaj tiv thaiv tsuas tuaj yeem txo qhov kev pheej hmoo ntawm cov tsos mob tshiab tshwm sim los ntawm Delta variant strain los ntawm 33%, thiab kev pheej hmoo rau Alpha los ntawm 50%, ob qho tib si qis dua qhov kev tiv thaiv kev tiv thaiv tom qab txhaj tshuaj tag nrho ntawm 2 koob.

Kev tiv thaiv kev ua tau zoo ntawm ob hom tshuaj tiv thaiv kab mob tshiab tiv thaiv B.1.617.2 thiab B.1.1.7 mutant hom |Cov ntaub ntawv [8]

Phau ntawv xov xwm kho mob tau tso cai "The Lancet" tau tshaj tawm lwm cov ntaub ntawv los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm Tebchaws Askiv thaum Lub Rau Hli 15, qhia tiasib qho tshuaj tiv thaiv kab mob tshiab thib ob (nrog rau ntau hom tshuaj tiv thaiv) tuaj yeem txo qis kev pheej hmoo ntawm kev mus pw hauv tsev kho mob.Txoj kev tshawb no kuj tau qhia tias tsawg kawg 28 hnub tom qab txhaj tshuaj thawj zaug, qhov kev tiv thaiv ntawm cov tshuaj tiv thaiv tau pom meej.

Raws li cov ntaub ntawv pov thawj, WHO thiab cov kws tshaj lij los ntawm ntau lub tebchaws tau rov hais dua qhov ntawdNws yog ib qho tseem ceeb heev los ua kom tiav tag nrho cov txheej txheem txhaj tshuaj tiv thaiv uas yuav tsum tau txhaj ob (lossis ntau dua), tshwj xeeb tshaj yog rau kev tiv thaiv COVID-19 hnyav thiab tuag.

Kev hloov pauv tsis tu ncua, kev tiv thaiv tsis tu ncua

Hauv cov neeg uas muaj cov tshuaj tiv thaiv tsawg, Delta variant muaj lub sijhawm sib kis tau sai.Kev tshawb fawb raws li cov ntaub ntawv sib txuas ntawm ze li ntawm 20,000 tus qauv txij li lub Plaub Hlis pom tiasnyob rau hauv cov cheeb tsam uas feem pua ​​​​ntawm cov neeg nyob hauv ua tiav tag nrho cov txheej txheem txhaj tshuaj tsawg dua 30%, qhov kev sib kis ntawm Delta variant strain yog ntau dua li ntawm lwm thaj chaw uas qhov kev txhaj tshuaj tiv thaiv ntau tshaj qhov feem pua.

Lwm cov kev tshawb fawb tseem pom tau tias qhov sib txawv loj ntawm kev txhaj tshuaj tiv thaiv kab mob tuaj yeem ua rau muaj qhov sib txawv ntawm cov neeg mob thiab kev mus pw hauv tsev kho mob los ntawm Delta variant nyob rau hauv ntau cheeb tsam.

Raws li tus mob coronavirus tshiab txuas ntxiv mus thoob ntiaj teb, kev hloov pauv ntawm tus kab mob yog yam tsis muaj kev zam.Ntxiv rau qhov Delta mutant strain nrog lub peev xwm kis tau zoo tshaj plaws kom deb li deb,Cov kws tshawb fawb tseem tab tom saib xyuas ntau hom mutant, suav nrog rau lwm xya hom mutant uas tau teev tseg tias yog "Mutant Strains to Be Observed" (VOI) los ntawm World Health Organization.

Yuav ua li cas los tiv thaiv tus kab mob coronavirus tsis tu ncua, Dr. Michael Ryan ntawm WHO ntseeg tias: "Kev hloov pauv ntawm cov noob tuaj yeem ua rau muaj kev hloov pauv ntawm tus yam ntxwv ntawm tus kabmob, xws li yuav kis tau rau tib neeg, nyob hauv cov tee dej ntev dua, thiab kis tau tsawg dua.Yuav ua rau kis kab mob, thiab lwm yam.Tab sis cov kab mob mutant no yuav tsis hloov qhov peb yuav ua, lawv ceeb toom peb kom ua txhua yam kev tiv thaiv uas tuaj yeem ua tau, thiab siv cov kev ntsuas nruj dua, suav nrog kev hnav lub qhov ncauj qhov ntswg, txo kev sib sau, thiab lwm yam. Peb tau hais ntxiv txog kev ntsuas. "

Hauv cov ntsiab lus, txawm hais tias Delta mutant strain tau nce kev kis kab mob, txo lub sijhawm incubation, thiab tus neeg mob tau mob ntau dua, tab sis nws tsis tuaj yeem tiv thaiv tag nrho.Txawm hais tias nws yog txhaj tshuaj tiv thaiv raws li qhov yuav tsum tau ua, lossis kev ntsuas xws li lub qhov ncauj qhov ntswg thiab kev sib cais, nws yuav tsum tau tswj kom zoo.Hauv kev tawm tsam nrog Delta mutant, qhov kev pib ua tau yog nyob rau hauv peb tus kheej txhais tes.

Cov ntaub ntawv

[1] Tracking SARS-CoV-2 variants Retrieved June 24, 2021 from https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/

[2] Delta coronavirus variant: cov kws tshawb fawb tau txais kev cuam tshuam, Rov qab Lub Rau Hli 24, 2021, los ntawm https://www.nature.com/articles/d41586-021-01696-3

[3] Cov kab mob Coronavirus tau nthuav tawm hauv Is Nrias teb - cov kws tshawb fawb paub txog tam sim no.Tau txais los ntawm http://www.nature.com/articles/d41586-021-01274-7/ May 11, 2021.

[4] SARS-CoV-2 variants of concern and variants under research in England.Tau txais los ntawm Lub Plaub Hlis 25, 2021 los ntawm https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/979818/Variants_of_Concern_VOC_Technical_Briefing_9_England.pdf

[5] Delta Variant ntawm Tus Kab Mob Coronavirus tuaj yeem muaj nyob hauv Asmeskas, tsis pub dhau lub lis piam.Tau txais Lub Rau Hli 23, los ntawm https://www.npr.org/sections/health-shots/2021/06/22/1008859705/delta-variant-coronavirus-unvaccinated-us-covid-surge

[6] Tau txais los ntawm Lub Rau Hli 26, 2021 los ntawm https://www.thepaper.cn/newsDetail_forward_13296668

[7] Tshaj tawm los ntawm txoj cai ntawm kev sib koom ua ke tiv thaiv thiab kev tswj hwm ntawm Xeev Pawg Neeg Saib Xyuas (Lub Rau Hli 11, 2021) Tau txais Lub Rau Hli 26, 2021 los ntawm http://www.gov.cn/xinwen/gwylflkjz160/index.htm

[8] Kev ua tau zoo ntawm cov tshuaj tiv thaiv COVID-19 tiv thaiv B.1.617.2 Variant.Tau txais los ntawm Lub Tsib Hlis 23, 2021 los ntawm https://khub.net/documents/135939561/430986542/Effectiveness+of+COVID-19+vaccines+against+the+B.1.617.2+variant.pdf/204e1020-d6 ac42 ua