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Emergence of SARS-CoV-2 B.1.1.7 Lineage

Tebchaws Asmeskas, Kaum Ob Hlis 29, 2020-Lub Ib Hlis 12, 2021

Lub caij ntuj sov E. Galloway, PhD 1 ;Prabasaj Paul, PhD 1 ;Duncan R. MacCannell, PhD 2 ;Michael A. Johansson, PhD 1 ;

John T. Brooks, MD 1;Adam MacNeil, PhD 1;Rachel B. Slayton, PhD 1 ;Suxiang Tong, PhD 1;Benjamin J. Silk, PhD 1 ;Gregory L. Armstrong, MD 2;

Matthew Biggerstaff, ScD 1 ;Vivien G. Dugan, PhD

Thaum Lub Ib Hlis 15, 2021, daim ntawv tshaj tawm no tau tshaj tawm raws li MMWRKev Tshaj Tawm ntxov ntawm MMWR lub vev xaib (https://www.cdc.gov/mmwr).

Lub Kaum Ob Hlis 14, 2020, Tebchaws Askiv tau tshaj tawma SARS-CoV-2 variant of concern (VOC), lineage B.1.1.7,kuj hu ua VOC 202012/01 los yog 20I/501Y.V1.* TheB.1.1.7 variant yog kwv yees tias tau tshwm sim rau lub Cuaj Hli2020 thiab tau dhau los ua qhov tseem ceeb tshaj plawsSARS-CoV-2 variant in England (1).B.1.1.7 taukuaj pom hauv ntau dua 30 lub teb chaws, suav nrog Tebchaws Meskas.Raws liLub Ib Hlis 13, 2021, kwv yees li 76 tus neeg mob ntawm B.1.1.7 muajtau kuaj pom hauv 12 lub xeev Asmeskas.Ntau kab ntawv pov thawjqhia tias B.1.1.7 kis tau zoo dua li covother SARS-CoV-2 variants (1-3).Tus qauv trajectory ntawmQhov kev hloov pauv no hauv Asmeskas nthuav tawm kev loj hlob sai thaum ntxov 2021,ua qhov txawv tshaj plaws nyob rau lub Peb Hlis.NceKev kis tus kab mob SARS-CoV-2 tuaj yeem cuam tshuam kev saib xyuas kev noj qab haus huvcov kev pab cuam, yuav tsum tau ncua sij hawm thiab siv nruj duantawm cov tswv yim kev noj qab haus huv rau pej xeem (4), thiab nce feem pua ​​​​ntawmkev tiv thaiv pej xeem xav tau los tswj kev kis thoob qhov txhia chaw.Nojkev ntsuas los txo kev sib kis tam sim no tuaj yeem txo qhov peev xwmcuam ​​tshuam ntawm B.1.1.7 thiab tso cai rau lub sijhawm tseem ceeb los txhaj tshuaj tiv thaivkev pab them nqi.Ua ke, txhim kho genomic soj ntsuamua ke nrog txuas ntxiv ua raws li cov pej xeem zooKev ntsuas kev noj qab haus huv, suav nrog kev txhaj tshuaj tiv thaiv, kev nyob deb ntawm lub cev,kev siv lub qhov ncauj qhov ntswg, ntxuav tes, thiab cais tawm thiab cais tawm, yuavyog qhov tseem ceeb rau kev txwv tsis pub kis tus kab mob SARS-CoV-2, tus kab mobuas ua rau tus mob coronavirus 2019 (COVID-19).Tswv yimkuaj cov neeg tsis muaj tsos mob tab sis muaj kev pheej hmoo siab duakev kis kab mob, xws li cov neeg raug SARS-CoV-2 lossis cov uas muajnquag tiv tauj nrog cov pej xeem, muab lwm yammuaj cib fim txwv tsis pub kis mus ntxiv.

Ntiaj teb no genomic soj ntsuam thiab ceev qhib-qhov chaw sharing ntawm kab mob genome sequences tau yooj yim nyob ze ntawm lub sijhawmSARS-CoV-2 evolving, detection, comparison, and tracking of evolving SARS-CoV-2variants uas tuaj yeem qhia txog kev noj qab haus huv rau pej xeem los tswj covkev kis kab mob mus thoob.Qee qhov kev hloov pauv hauv cov kab mob genometshwm sim thiab tom qab ntawd thim rov qab, lwm tus tuaj yeem xaiv qhov advan xaivtage rau lub variant, nrog rau kev txhim kho transmissibility, yog li ntawdxws li ib tug variant yuav sai dominate lwm circulating variants.

Thaum ntxov ntawm kev sib kis, qhov sib txawv ntawm SARS-CoV-2 muajD614G kev hloov pauv hauv cov kab ke (S) protein uas ncereceptor binding avidity sai dhau los ua qhov tseem ceeb hauv ntauthaj chaw thaj tsam (5,6).Thaum lub caij nplooj zeeg lig 2020, ntau lub tebchaws tau tshaj tawm txog kev kuaj pomSARS-CoV-2 variants uas kis tau zoo dua.Ntxiv raumus rau B.1.1.7 variant, tseem ceeb variants muaj xws li B.1.351kab mob thawj zaug pom hauv South Africa thiab tsis ntev los no tau txheeb xyuasB.1.1.28 subclade (renamedP.1) kuaj pom hauv plaub tus neeg taug kevlos ntawm Brazil thaum lub sij hawm niaj hnub tshuaj ntsuam ntawm Haneda (Tokyo)tshav dav hlau.§ Cov variants no muaj lub hnub qub ntawm cov noob caj noob cestions, suav nrog hauv S protein receptor-binding domain,Nws yog ib qho tseem ceeb rau kev khi rau tus tswv tsev cell angiotensin-hloov enzyme-2 (ACE-2) receptor los pab txhawb tus kab mobnkag.Cov ntaub ntawv pov thawj qhia tias muaj lwm yam kev hloov pauv hauv cov novariants yuav confer tsis tsuas yog nce transmissibility tab siskuj tseem yuav cuam tshuam rau kev ua haujlwm ntawm qee qhov kev kuaj mob hauv lub sijhawmrov qab transcription-Polymerase saw Reaction (RT-PCR)kev soj ntsuamthiab txo kev raug mob rau neutralizing cov tshuaj tiv thaiv(2,3,5-10).Cov ntaub ntawv tsis ntev los no tau sau tseg thawj rooj plaub ntawmSARS-CoV-2 reinfection in Brazil with a SARS-CoV-2 variantuas muaj qhov hloov pauv E484K, ** uas tau pomkom txo neutralization los ntawm convalescent sera thiab monoclonalcov tshuaj tiv thaiv (9,10).

Daim ntawv tshaj tawm no tsom mus rau qhov tshwm sim ntawm B.1.1.7 variantnyob rau hauv lub tebchaws United States.Raws li lub Ib Hlis 12, 2021, tsis yogB.1.351 los yog P.1 variants tau kuaj pom nyob rau hauvTebchaws Meskas.Yog xav paub ntxiv txog SARS-CoV-2ntau yam kev txhawj xeeb, CDC tuav lub vev xaib nplooj siab raumuab cov ntaub ntawv hais txog kev tawm tsam SARS-CoV-2 variants.††

 B.1.1.7 kab (20I/501Y.V1)

B.1.1.7 variant yog kev hloov pauv hauv cov protein S(N501Y) uas cuam tshuam rau kev sib haum xeeb ntawm receptor-bindingsau npe.Qhov no variant muaj 13 lwm yam B.1.1.7 kab-txhais kev hloov pauv (Table), ob peb yam uas muaj nyob rau hauv S protein,suav nrog kev tshem tawm ntawm txoj haujlwm 69 thiab 70 (del69-70) ibevolved spontaneously nyob rau hauv lwm yam SARS-CoV-2 variants thiab yoghypothesized kom nce transmissibility (2,7).Kev tshem tawmntawm txoj haujlwm 69 thiab 70 ua rau S-gene phiaj tsis ua haujlwm (SGTF)tsawg kawg yog ib qho RT-PCR-raws li kev kuaj mob (xws li, nrog rauThermoFisher Taq Path kev tshuaj xyuas COVID-19, B.1.1.7 varintsaum thiab lwm yam variants nrog lub del69-70 ua qhov tsis zootshwm sim rau S-gene lub hom phiaj thiab ib qho txiaj ntsig zoo rau lwm qhov obhom phiaj);SGTF tau ua tus tso npe hauv tebchaws United Kingdomrau kev txheeb xyuas qhov teeb meem B.1.1.7 (1).Ntau kab ntawv pov thawj qhia tias B.1.1.7 ntau duakis tau zoo piv nrog rau lwm yam SARS-CoV-2variants circulating nyob rau hauv lub tebchaws United Kingdom.UK cheeb tsam nrogntau dua ntawm B.1.1.7 ib ntus muaj kev sib kis sai duakev loj hlob dua li lwm thaj chaw, kev kuaj mob nrog SGTF ncesai dua li qhov tsis yog-SGTF kuaj mob hauv tib thaj chaw, thiab antau dua ntawm kev sib cuag tau kis los ntawm cov neeg mob indexnrog B.1.1.7 kab mob dua los ntawm index cov neeg mob nrogLwm qhov sib txawv (1,3).Variant B.1.1.7 muaj peev xwm nce US yiasdemic trajectory nyob rau lub hlis tom ntej.Txhawm rau piav qhia qhov txiaj ntsig no,ib qho yooj yim, ob-variant compartmental qauv tau tsim.Tam sim no US prevalence ntawm B.1.1.7 ntawm tag nrho cov circulatingCov kab mob tsis paub tab sis xav tias yog <0.5% raws li covTsawg tus neeg mob kuaj pom thiab SGTF cov ntaub ntawv (8).Rautus qauv, thawj qhov kev xav suav nrog B.1.1.7 prevalencentawm 0.5% ntawm tag nrho cov kab mob, SARS-CoV-2 tiv thaiv los ntawmyav dhau los tus kab mob ntawm 10%-30%, lub sijhawm sib txawv ntawm kev yug me nyuamtus naj npawb (R t) ntawm 1.1 (muag tab sis nce kev sib kis)los yog 0.9 (txo kev sib kis) rau cov kev hloov pauv tam sim no, thiab raug xa tawm ntawm 60 tus neeg mob rau 100,000 tus neeg hauv ib hnub rauLub Ib Hlis Ntuj Tim 1, 2021. Cov kev xav no tsis muaj tseebib qho chaw hauv Teb Chaws Asmeskas, tab sis theej, qhia qhov dav dav ntawmtej yam kev mob tshwm sim thoob plaws lub tebchaws.Qhov kev hloov hauv R t dhaulub sij hawm tshwm sim los ntawm kev tiv thaiv kab mob thiab nce prevalence ntawm B.1.1.7, tau ua qauv, nrog rau B.1.1.7 R t assumedlos ua qhov tsis tu ncua 1.5 npaug ntawm R t ntawm cov hloov pauv tam sim no, raws liThawj qhov kwv yees los ntawm United Kingdom (1,3).Tom qab ntawd, qhov muaj feem cuam tshuam ntawm kev txhaj tshuaj tiv thaiv tau ua qauvkwv yees tias 1 lab txhaj tshuaj tiv thaiv ib zaughnub pib Lub Ib Hlis 1, 2021, thiab qhov kev tiv thaiv 95%.tau ua tiav 14 hnub tom qab tau txais 2 koob tshuaj.Tshwj xeeb,tiv thaiv kab mob los ntawm cov kab mob tam sim no lossis covB.1.1.7 variant yog assumed, txawm tias cov hauj lwm zoo thiabLub sijhawm tiv thaiv kab mob tseem tsis paub meej,vim cov no tsis yog thawj qhov kawg ntawm kev sim tshuajrau cov tshuaj tiv thaiv thawj zaug.Hauv cov qauv no, B.1.1.7 prevalence yog pib qis, tsis tau vimnws yog transmissible ntau dua li tam sim no variants, nws exhibitsKev loj hlob sai sai thaum ntxov 2021, dhau los ua qhov tseem ceeb variAnt nyob rau lub Peb Hlis (Daim duab 1).Seb kis tau tus mob tam sim novariants yog nce (thawj R t = 1.1) los yog maj mam txo(pib R t = 0.9) hauv Lub Ib Hlis, B.1.1.7 tsav kev hloov pauv ntaunyob rau hauv lub kis tau tus mob trajectory thiab ib tug tshiab theem ntawm exponentialkev loj hlob.Nrog kev txhaj tshuaj tiv thaiv kab mob, covCov kab mob kis thaum ntxov tsis hloov pauv thiab B.1.1.7 kis tautseem tshwm sim (Daim duab 2).Txawm li cas los xij, tom qab B.1.1.7 dhau los ua tusdominant variant, nws kis tau tus mob txo.Cov txiaj ntsig ntawm kev txhaj tshuaj tiv thaiv kev txo qis kev sib kis nyob zelub sij hawm yog qhov loj tshaj nyob rau hauv qhov scenario uas kis tau tus mobtwb txo (pib R t = 0.9) (Daim duab 2).Thaum ntxov siv zog ntawdtuaj yeem txwv kev sib kis ntawm B.1.1.7 variant, xws li universal thiabnce kev ua raws li cov tswv yim txo kev noj qab haus huv rau pej xeem,yuav cia sijhawm ntxiv rau kev txhaj tshuaj tiv thaiv txuas ntxiv kom ua tiav siab duakev tiv thaiv pej xeem.

Kev sib tham

Tam sim no, tsis muaj qhov paub qhov txawv ntawm cov txiaj ntsig kho mobtxuam nrog SARS-CoV-2 variants piav;txawm li cas los xij,kev sib kis ntau dua yuav ua rau muaj mob ntau ntxiv, nce ntxivtus naj npawb ntawm cov neeg tag nrho uas xav tau kev kho mob, exacerbating lub nra ntawm ib qho kev kho mob uas twb muaj lawm,thiab ua rau muaj neeg tuag ntau dua.Txuas ntxiv kev soj ntsuam genomictxhawm rau txheeb xyuas qhov xwm txheej B.1.1.7, nrog rau qhov tshwm sim ntawm lwm yamvariants ntawm kev txhawj xeeb nyob rau hauv lub tebchaws United States, yog ib qho tseem ceeb rau lubCOVID-19 cov lus teb rau pej xeem kev noj qab haus huv.Raws li SGTF cov txiaj ntsigtuaj yeem pab txheeb xyuas cov xwm txheej B.1.1.7 uas tuaj yeem lees paublos ntawm kev ua ntu zus, txheeb xyuas qhov tseem ceeb ntawm qhov sib txawv uas tsis tshwm simSGTF tsuas yog tso siab rau kev soj ntsuam raws kab ke.

 

 

 

Variant npe

Kev txheeb xyuas thawj zaug  

Cov yam ntxwv hloov pauv

(protein: kev hloov pauv)

Tsis muaj qhov xwm txheej tam sim no uas tau lees paub Tsis muaj

lub teb chaws nrog

ua ntu zus

Qhov chaw Hnub tim Tebchaws Meskas Thoob ntiaj teb  
B.1.1.7 (20I/501Y.V1) United Kingdom Sep 2020 ORF1ab: T1001I, A1708D, I2230T,

ib 3675-3677 TZS

s: 69 ua-70 HV, del 144 Y, N501Y,

A570D, D614G, P681H, T761I,

S982A, D1118H

ORF8: Q27stop, R52I, Y73C

N: D3L, S235F

76 15, 369 ib 36
B.1.351 (20H/501Y.V2) South Africa Peb Hlis 2020 ORF1ab: K1655N

ib: p71l

N: T205I

S: K417N, E484K, N501Y, D614G,

A701v

0 415 13

 

P.1 (20J/501Y.V3 Brazil thiab Nyiv Peb Hlis 2021 ORF1ab: F681L, I760T, S1188L,

K1795Q, ib 3675-3677 SWB, E5662D

S: L18F, T20N, P26S, D138Y, R190S,

K417T, E484K, N501Y, D614G,

H655Y, T1027I

ORF3a: C174G

ORF8: E92K

qw 9:77e

ORF14: V49L

N: P80 R

0 35 2

 

Cov ntawv luv: del = deletion;E = hnab ntawv protein;N = nucleocapsid protein;ORF = qhib kev nyeem ntawv;S = protein ntau.

Kev paub hauv tebchaws United Kingdom thiab B.1.1.7 qauvnthuav tawm hauv tsab ntawv ceeb toom no qhia txog qhov cuam tshuam ntau kisvariant tuaj yeem muaj nyob ntawm tus lej ntawm cov neeg mob.Covnce transmissibility ntawm no variant yuav tsum tau ib qho ntxivnruj me ntsis kev siv tshuaj tiv thaiv thiab mitigakev ntsuas (piv txwv li, nyob deb, npog, thiab tes huv si)los tswj kev sib kis ntawm SARS-CoV-2.Cov kev ntsuas no yuav yogzoo dua yog tias lawv tau teeb tsa sai dua tom qabkom qeeb qhov pib kis ntawm B.1.1.7 variant.Kev siv zog raunpaj cov txheej txheem kev kho mob rau kev nce ntxiv hauv cov xwm txheej yoglav.Nce transmissibility kuj txhais tau tias siab duatshaj qhov kev cia siab ntawm kev txhaj tshuaj tiv thaiv yuav tsum tau ua kom tiavua tiav tib theem ntawm kev tswj kab mob los tiv thaiv pej xeempiv nrog tsawg transmissible variants.Hauv kev koom tes nrog kev kawm, kev lag luam, xeev, thaj chaw,pawg neeg, thiab cov koom tes hauv zos, CDC thiab lwm lub koom haum tseem fwvyog kev sib koom tes thiab txhim kho genomic soj ntsuam thiabkev mob siab rau tus kab mob thoob plaws Tebchaws Meskas.CDCtswj xyuas US sequencing zog los ntawm SARS-CoV-2Sequencing rau Public Health Response Emergency,Epidemiology, thiab soj ntsuam (SPHERES)§§koom nrog,uas suav nrog kwv yees li 170 lub koom haum koom nrog thiab txhawb kev qhib cov ntaub ntawv sib koom los pab txhawb kev siv SARS-CoV-2cov ntaub ntawv sib lawv liag.To track SARS-CoV-2 viral evolution, CDC issiv multifaceted genomic soj ntsuam kom nkag siabcov txheej txheem epidemiological, immunologic, thiab evolutionary txheej txheemuas zoo li tus kab mob phylogenies (phylodynamics);qhia kev tawm tsamkev tshawb nrhiav;thiab pab txhawb kev tshawb nrhiav thiab tus cwj pwmtion ntawm muaj peev xwm rov ua tau cov kab mob, tshuaj tiv thaiv kab mob, thiabcov kab mob variants tshwm sim.Lub Kaum Ib Hlis 2020, CDC tau tsimNational SARS-CoV-2 Strain Surveillance (NS3) programlos txhim kho tus neeg sawv cev ntawm domestic SARS-CoV-2ua ntu zus.Qhov kev zov me nyuam koom tes nrog 64 Asmeskas pej xeemcov chaw soj ntsuam kev noj qab haus huv los txhawb kev soj ntsuam genomic;NS3 tseem tab tom tsim cov khoom sau ntawm SARS-CoV-2 specimens and sequences los txhawb pej xeem kev noj qab haus huv teb thiab scientifickev tshawb fawb los ntsuas qhov cuam tshuam ntawm kev hloov pauv ntawmuas twb muaj lawm pom zoo kev tiv thaiv kev kho mob.CDC muajkuj tau cog lus nrog ntau lub chaw kho mob loj ua lag luamtories kom nrawm nrawm ntau txhiab tus SARS-CoV-2-cov qauv zoo txhua lub hlis thiab tau pab nyiaj xya txoj kev kawmcov koom haum los ua kev soj ntsuam genomic hauv kev koom tesnrog cov koom haum saib xyuas kev noj qab haus huv rau pej xeem, yog li ntxiv qhov tseem ceeb raumuaj cov ntaub ntawv tshawb xyuas genomic raws sijhawm los ntawm thoob plawsTebchaws Meskas.Ntxiv rau cov phiaj xwm hauv tebchaws no,ntau lub xeev thiab cov chaw saib xyuas kev noj qab haus huv hauv nroog tau ua raws

FIGURE 1. Simulated case incidence trajectories* of current SARS-CoV-2 variants and the B.1.1.7 variant,xav tias tsis muaj tshuaj tiv thaiv hauv zej zogthiab pib R t = 1.1 (A) lossis pib R t = 0.9 (B) rau cov hloov pauv tam sim noTebchaws Asmeskas, Lub Ib Hlis-Plaub Hlis 2021

 

duab 1
duab 2
Cov ntawv luv
duab 1

SARS-CoV-2 kom nkag siab zoo dua hauv zos kis kab mob thiabtxhawb pej xeem kev noj qab haus huv teb rau kev sib kis.Cov kev tshawb pom nyob rau hauv tsab ntawv ceeb toom no muaj tsawg kawg yog peb limikev.Ua ntej, qhov loj ntawm qhov nce hauv transmissibility nyob rau hauv lub tebchaws United States piv nrog uas pom nyob rau hauv lubUnited Kingdom tseem tsis meej.Qhov thib ob, qhov nthuav dav ntawmB.1.1.7 hauv Tebchaws Meskas kuj tsis paub txog lub sijhawm no, tab sisnrhiav kom paub txog qhov sib txawv thiab kwv yees ntawm kev nthuav dav yuav txhim khonrog kev txhim kho US kev soj ntsuam xyuas.Thaum kawg, hauv zos mitigation ntsuas kuj hloov tau heev, ua rau variation nyob rau hauvR t.Cov txiaj ntsig tshwj xeeb tau nthuav tawm ntawm no yog nyob ntawm simulations thiab xav tias tsis muaj kev hloov pauv hauv kev txo qis dhau lub Ib Hlis 1.Qhov nce kis tau ntawm B.1.1.7 variant tsov rogrants nruj kev siv cov tswv yim kev noj qab haus huv rau pej xeemtxo kev sib kis thiab txo qhov muaj peev xwm cuam tshuam ntawm B.1.1.7,yuav lub sijhawm tseem ceeb los txhawb kev txhaj tshuaj tiv thaiv.CDC covqauv cov ntaub ntawv qhia tau hais tias universal siv thiab nce compliance nrog kev txo qis thiab kev txhaj tshuaj tiv thaiv yog qhov tseem ceeb rautxo tus naj npawb ntawm cov neeg mob tshiab thiab cov neeg tuag ntau heev hauv covlub hlis tom ntej.Tsis tas li ntawd, kev sim cov tswv yim ntawm cov neeg tsis muajCov tsos mob ntawm COVID-19, tab sis leej twg muaj kev pheej hmoo ntxiv raukis tau tus kab mob SARS-CoV-2, muab lwm txoj hauv kev rautxwv kev sib kis tsis tu ncua.Ua ke, txhim kho genomic soj ntsuamlance ua ke nrog nce kev ua raws li kev noj qab haus huv rau pej xeemCov tswv yim txo qis, suav nrog kev txhaj tshuaj tiv thaiv, kev nyob deb ntawm lub cevnyob rau hauv, siv lub qhov ncauj qhov ntswg, tes huv si, thiab cais thiab cais tawm,yuav yog qhov tseem ceeb rau kev txwv tsis pub kis ntawm SARS-CoV-2 thiabtiv thaiv pej xeem kev noj qab haus huv.

Kev lees paub

Cov tswv cuab ntawm Sequencing for Public Health EmergencyTeb, Epidemiology thiab Soj ntsuam pawg koom haum;xeev thiab hauv zoscov chaw kuaj mob pej xeem;Association ntawm Public Health Laboratories;CDC pab neeg teb COVID-19;Tus kab mob ua pa ceg,Division of Viral Diseases, CDC.Committee of Medical Journal Editors daim foos rau kev nthuav tawm cov peev xwmkev tsis sib haum xeeb.Tsis muaj peev xwm tsis sib haum xeeb ntawm kev txaus siab tau nthuav tawm.

Cov ntaub ntawv

1. Public Health England.Investigation of novel SARS-CoV-2 variant: variant of concern 202012/01, technical briefing 3. London, United Kingdom: Public Health England;2020. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/950823/Variant_of_Concern_VOC_202012_01_Technical_Briefing_3_-_England.pdf
2. Kemp SA, Harvey WT, Datir RP, et al.Recurrent emergence and transmission of SARS-CoV-2 spike deletion ΔH69/V70.bioRxiv[Preprint tshaj tawm online Lub Ib Hlis 14, 2021].https://www.biorxiv.org/content/10.1101/2020.12.14.422555v4
3. Volz E, Mishra S, Chand M, et al.Transmission of SARS-CoV-2 lineage B.1.1.7 in England: insights from linking epidemiological and genetic data.medRxiv [Preprint tshaj tawm online Lub Ib Hlis 4, 2021].https://www.medrxiv.org/content/10.1101/2020.12.30.20249034v2
4. Honein MA, Christie A, Rose DA, et al.;CDC pab neeg teb COVID-19.Summary of guidance for public health strategies to address high-level of community transmission of SARS-CoV-2 and related deaths, Kaum Ob Hlis 2020. MMWR Morb Mortal Wkly Rep 2020;69:1860–7.PMID:33301434 https://doi.org/58500/10/2020.
5. Volz E, Hill V, McCrone JT, et al.;COG-UK Consortium.Kev ntsuas qhov cuam tshuam ntawm SARS-CoV-2 spike mutation D614G ntawm kev kis thiab kab mob.Cell 2021; 184:64–75.e11.PMID: 33275900 https://doi.org/10.1016/j.cell.2020.11.020
6. Korber B, Fischer WM, Gnanakaran S, et al.;Sheffield COVID-19 Genomics Group.Taug qab cov kev hloov pauv hauv SARS-CoV-2 spike: pov thawj tias D614G nce kev kis tus kab mob COVID-19.Cell
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